Marquinhos and Cavani spent seven years together in the French capital, where the former Palermo striker cemented legendary status by becoming the club’s all-time top scorer with 200 goals in all competitions before leaving for Manchester United this season.
Brazil will look to continue their flawless start to the qualifiers as they aim for their fourth win on the spin against Oscar Tabarez’s men in Montevideo.
Having missed the chance to square off with their club sides in the Champions League last month, Marquinhos will get to meet Cavani for the first time since the striker’s departure from the Parc des Princes, and he has warned his teammates to keep a close eye on one of Europe’s most lethal frontmen in the last decade.
"For me, it was very good to work with Cavani because he is a great attacker," he said.
"In confrontations you had to be very careful with him and try to cancel him in the best way.
"I really like to face great attackers, to be able to raise my level and train in the best way. That is what makes you improve and grow every day.
"Cavani is a very decisive player and one who gives a lot to his teams. We know how important he has been for his team. He plays everywhere on the field, attacks and defends.
"We will have to be 100 per cent focused because at the slightest mistake, he can score a goal."