Neves has been courting interest from some of Europe's biggest clubs after another fine season at the Molineux Stadium.
The 25-year-old has been linked with the likes of Manchester United and Barcelona, having joined Wolves for £16m in the summer of 2017.
Neves has scored four goals in 28 Premier League appearances this season but is currently sidelined with a knee injury.
"I don't know if it's Manchester United or other teams, what I know is we have a special player with us," said Lage.
"What he is doing this season is very good. I think also the way we play, he can show a better Ruben, and also the way he plays puts our team on a different level.
"When you have that player, the best thing to do is improve his salary and years of contract.
"But who knows, when you have a top player like him in that specific position, that can defend and attack, and is a top professional and a great man, the big teams are there with £100m to buy these kinds of players."
Lage is no stranger to losing top players for big money, having sold Joao Felix to Atletico Madrid for £113m during his time as Benfica manager and he admits it will be difficult to turn down a similar offer for Neves.
"I would have preferred to remain with Joao Felix in Benfica, but 120m euros came and he left," added Lage.
"It depends on the strategy of Wolves also. That's why it was so hard to find players in the last two transfer windows.
"We want to find the best players at the right price and the right age to help us, then after two or three years they can give us economical profit.
"It's not just about Wolves, in these days which club can refuse a proposal of 80, 90 or 100 million pounds? Five or six."
