The Bianconeri build on their midweek victory over Spezia with an emphatic win over Simone Inzaghi’s men to go third on the Serie A table.
Joaquin Correa had put the visitors ahead in the opening 14 minutes but Adrien Rabiot pulled parity for the hosts six minutes before the interval.
Striker Alvaro Morata put Pirlo’s men ahead twelve minutes after the break and swiftly settled Lazio’s defeat from the penalty spot three minutes later.
Speaking to the media after the game, Pirlo was happy his side stepped up to deal with the threat posed by the Rome-based team.
“We didn’t let our heads drop, we started to step up the tempo and that was the most important thing,” the Italian coach told DAZN.
Juventus transformed their line-up with Cristiano Ronaldo benched, Danilo in midfield for a 4-2-3-1 formation and Federico Bernardeschi at left-back.
Pirlo added: “We thought about Tuesday’s game, we have some players who have barely trained, like Cuadrado and Arthur. We knew this game was like a final, some had to play in new positions and showed great professionalism and spirit of sacrifice.
“The most important thing was the three points. Danilo was ready to work in central midfield, while Bernardeschi deserves all the compliments for playing as a left-back.
“What I liked the most was the reaction of the team, as we didn’t accept being behind in such a delicate and important game, so it was that spirit I appreciated.”