Some of the big European teams have already fallen in the previous round. Serie A side Napoli could not beat Granada, and Young Boys secured a place in the last 16 at the expense of Bayer Leverkusen.
The biggest game of the round sees 2017 winners Manchester United take on AC Milan, while AS Roma have been drawn in a mouthwatering fixture against last season semi-finalists Shakhtar Dontesk.
Arsenal’s reward for knocking Benfica out will see them take on Olympiacos, a side which eliminated them from this competition last season.
Jose Mourinho’s Tottenham Hotspur have been handed a Dinamo Zagreb test, while Ajax get Young Boys.
The last 16 first legs will be played on March 11 with the second legs a week later on March 18.
The final for this season’s Europa League will be played on 26 May 2021 at the Stadion Miejski in Gdańsk, Poland.
The Europa League last-16 draw in full
Ajax vs Young Boys
Dynamo Kiev vs Villarreal
Roma vs Shakhtar Donetsk
Olympiakos vs Arsenal
Dinamo Zagreb vs Tottenham Hotspur
Manchester United vs AC Milan
Slavia Prague vs Rangers
Granada vs Molde
