Mourinho believes Spurs does not seem to learn at the highest level and they keep repeating similar errors.
Heung-Min Son put the hosts ahead inside the opening three minutes but his effort was ruled out as he was deemed offside by VAR.
Roberto Firmino broke the deadlock on the cusp of halftime after tapping home a low cross from Sadio Mane.
Spurs had to play the second half without talisman Harry Kane due to injury and defender Trent Alexander-Arnold scored the visitors’ second goal two minutes after the interval.
Midfielder Pierre-Emile Hojberg swiftly halve the deficit with a first time shot two minutes later.
Mohamed Salah looked to have added a third for Liverpool after a blistering counter attack, but VAR once again intervened to overturn the goal for a Firmino handball in the build-up.
Sadio Mane restored Liverpool’s two-goal cushion midway through the second half and that was enough to beat Mourinho’s men.
"Some of the guys are very disappointed because some had a very good performance but we were punished by individual mistakes,” Mourinho said after the game.
"Nothing new to learn, at the highest level you make individual mistakes normally you're punished and we were punished by individual mistakes so it's nothing new.
"It's very hard to resist so many defensive individual mistakes - unless you score four goals against Liverpool. Every time we came back the next mistake was coming.
"The first ball was the beginning of everything because in the first minute a mistake and then a chance for Sadio Mane.”
“The team was confident, playing well, Son Heung-min goal was obviously offside, then when the game was stable and we were very much in the game and then comes the goal that is a replica of the first chance they had. So minute one and minute 48, we made the same mistake.
"At half time we lost Harry Kane and in the first minute of the second half another mistake another goal.
“Good reaction at 2-1, the team fighting and bringing Liverpool back and then one more mistake and it's 3-1. Very difficult to fight against so many mistakes."
