Jesus picked up the injury in City’s opening Premier League game against Wolverhampton Wanderers on Monday.
The 23-year-old played the full 90 minutes and scored City’s third goal in the 3-1 win but an injury was detected after the game and Jesus subsequently missed Thursday’s Carabao Cup third round win over Bournemouth at the Etihad Stadium.
Jesus has been ruled out of Brazil’s upcoming World Cup qualifiers against Bolivia and Peru, with the Brazil Football Confederation (CBF) announcing that he has been replaced in the squad by Hertha Berlin’s Matheus Cunha.
"Striker Matheus Cunha, from German club Hertha Berlin, was called up by coach Tite for the first two rounds of the qualifiers for the FIFA World Cup Qatar 2022. He replaces the injured Gabriel Jesus, of Manchester City," a CBF statement read on Friday.
"On Wednesday, the English team contacted the doctor of the Brazilian National Team, Rodrigo Lasmar, reporting the player's injury detected after Monday's game against Wolverhampton in the Premier League."
Jesus’ injury means that Manchester City have no recognised senior striker in their ranks, with Sergio Aguero already sidelined with a knee problem that could keep him out for the next two months.