The 39-year-old is the U.S Women’s second most capped player of all-time with 312 appearances to her name, scoring 128 goals.
Lloyd made her U.S debut in 2005 and has won two FIFA Women’s World Cups and two Olympic Games gold medals.
She was named FIFA Women’s World Player Of The Year in 2015 and has represented the likes of Chicago Red Stars, Western New York Flash and Houston Dash at club level.
"When I first started out with the national team in 2005, my two main goals were to be the most complete soccer player I could be and to help the team win championships." said Lloyd.
"Every single day I stepped out onto the field, I played as if it was my last game. I never wanted to take anything for granted, especially knowing how hard it is to get to the top, but even harder to stay at the top for so long."
"I would like to thank US Soccer for helping to provide the opportunities and memories that will last a lifetime. I am forever grateful to have represented the crest and to be able to play for my country for the last 17 years," Lloyd added.
"I will continue to support and cheer this team on and continue to find ways to help grow the game and inspire the next generation.
"To end my career knowing my family was able to be by my side and share this last chapter with me could not have been any more special. We will all have a lot more time to spend together now, and especially with my husband Brian, who has been my rock and biggest support system for all these years.
"We are both looking forward to starting this next chapter of our lives without my everyday grind of training and playing, but I will most likely need to another outlet for my competitiveness! Perhaps that will be golf?"