A fixture that featured as the Champions League finals of 2009 and 2011 show the levels these two teams have dropped in recent seasons.
Habitual winners Sevilla will play PSV after dropping down from the Champions League while Juventus will battle FC Nantes.
Shakhtar Donetsk are up against Rennes, Ajax Amsterdam tackle Union Berlin and RB Salzburg meet AS Roma
AS Monaco's opponents will be Bayer Leverkusen while Sporting Lisbon will take on Midjylland.
Frankfurt are the current holders of the Europa League after defeating Rangers on penalties at the Ramon Sanchez Pizjuan in May.
This season's Europa League final will be played at the Puskas Arena in Hungary on May 31, 2023.
Europa League Knockout Round Play-Off Draw In Full:
Barcelona vs Manchester United
Juventus vs Nantes
Sporting Lisbon vs Midjylland
Shakhtar Donetsk vs Rennes
Ajax Amsterdam vs Union Berlin
Bayer Leverkusen vs AS Monaco
Sevilla vs PSV
RB Salzburg vs AS Roma
