This is the second time Salah has won the honour, with his first triumph coming in the 2017/2018 campaign.
Salah won the Premier League golden boot after scoring 23 goals as well as the Playmaker of the season award for providing the most assists with 13.
The 29-year-old came out on top in a shortlist that included the likes of Harry Kane, Cristiano Ronaldo, Kevin De Bruyne, Sadio Mane and Virgil Van Dijk.
Salah joins the likes of De Bruyne, Ronaldo, Thierry Henry, Gareth Bale, Mark Hughes and Alan Shearer, who have all won the PFA top gong twice.
The Egypt international said: “It’s a great honour to win a trophy, individual or collective and this one is big so, I'm very happy and very proud of that.
"This one is a really good one to win, especially because it’s voted by players. It shows you that you’ve worked really hard and you get what you worked for.
"I have my room with trophies in a cabinet and I made sure that I had another space for one more. I always keep space and just try to imagine that the trophies are going to come.”
"When you get older, you feel like you’re more stable and you know exactly what you want from football so I’m just trying to really chill and help the team. That’s why I think I also won the Playmaker award, because it’s like you’re more aware of the game, so you just try to make the people next to you better and try to make yourself better as well.”