Isco joined Real Madrid from Malaga in the summer of 2013 and won five UEFA Champions League titles, three La Liga trophies, one Copa del Rey among other honours.
The Valencia youth product made 353 appearances in total for Los Blancos, scoring 53 goals and laying on another 56 assists for his teammates.
In a farewell message to the Real Madrid family on Instagram, Isco wrote: "When I was in Malaga and I knew I had to leave, I signed up with another team. But Real Madrid knocked on my door and Real Madrid cannot and should not be told no, although there are always exceptions."
"I remember telling my people Madrid hasn't won the Champions League for many years and I have a feeling that it's close and LA DÉCIMA arrived, everything that comes after is history.
"Nine years later my time at the club ends, which has made it possible for me to fulfil all the dreams I had when I was little.
"Apart from fulfilling dreams, winning more titles than I had imagined, playing with the greatest, meeting incredible people: I HAVE HAD A F*CKING TIME AND 'QUE ME QUITEN LO BAILAO'.
"Because without a doubt I keep the good and I hope you do too!!
"I want to thank my teammates, coaches, coaching staff, physios, kit men, workers at Valdebebas and Santiago Bernabeu for all the work, love and support that everyone needs and that I have never lacked.
"I also want to thank the fans who welcomed me in an incredible way from day one and who accompany this team in every part of the world!
"By the way, yesterday I was telling a friend that I didn't understand why they were holding the Cibeles party [to celebrate their 14th European Cup success] if number 15 is on its way hahahaha."
He ended his farewell message by saying: "Goodbye and Hala Madrid."
