Manchester City have not won a Premier League game at Anfield for the past 16 years although they came close last season when Riyad Mahrez missed a late penalty in an eventual 0-0 draw.
Unbeaten Liverpool are top of the table after eleven matchdays and could extend their lead over the champions to nine points with victory on Sunday.
Manchester City go into the game sweating on the fitness of first choice goalkeeper Ederson, who picked up a thigh strain and was substituted at halftime against Atalanta in the UEFA Champions League on Wednesday.
Captain David Silva has also been ruled out while summer signing Rodri is doubtful, with the likes of Aymeric Laporte, Leroy Sane and Oleksander Zinchenko all long-term absentees.
City’s injury problems has seen Pep Guardiola deploy Fernandinho in the centre of defence recently, but the former Shakhtar Donetsk man is not looking to use that as an excuse as the champions search for a long-awaited victory.
“We go there and try to win the game," the Brazilian said.
"The mentality is always try to win the game, as we did [against Atalanta] from the first minute."
"There's always a first time in life, no?” said the 34-year-old.
“We are searching for this first time to win at Anfield. I am confident we can go there and try to win the game.
"Of course, we will see with Ederson's situation. We are going to train and the medical staff are going to check him and we are going to see if he will be fit or not for Sunday."
