Raiola's family announced the sad news just days after a death hoax went viral about the 54-year-old.
Raiola was arguably the world's biggest football agent with his clients also including the likes of, Zlatan Ibrahimovic, Gianluigi Donnarumma, Erling Haaland, Mario Balotelli and Romelu Lukaku.
He brokered some of football's biggest deals, including Pogba's then world record £89m transfer from Juventus to Manchester United in the summer of 2016.
The world of football have been paying tribute to Raiola following his passing, with Pogba and De Ligt adding their voices on social media.
"I honestly am not ready to write this message and I think I never will be," De Ligt wrote.
"It’s too early for us players, for your family but especially for you. You had so many dreams to fulfil, so many things left to do… you were always right in the end. You knew how the world worked. Nothing is impossible and you showed that to the whole world.
"You fought for your players together with your team and that’s why you were so loved by all of them. Because as you always said: they are my sons, my family.
"Mino, I will miss you for everything… to be my agent, but especially to be my best friend."
In a series of photos of himself and Raiola, Pogba added: "Always in my heart – thank you Mimi".