Some big teams have already said goodbye to the competition including the likes of Borussia Dortmund and Napoli, who were eliminated by Rangers and Barcelona respectively.
Habitual winners Sevilla have been paired with West Ham United while Barcelona will face Galatasaray.
Atalanta will do battle with Bayer Leverkusen and Rangers take on Red Star Belgrade.
The first legs will take place on March 10 and the return legs are on March 17.
The final for this season’s Europa League will be held at Sevilla's Ramon Sanchez Pizjuan stadium in Spain on May 18 2022.
Villarreal are the current holders of the competition after beating Manchester United on penalties at the Gdansk Arena in Poland in May last year.
Europa League Round Of 16 Draw In Full:
Real Betis Vs Eintracht Frankfurt
RB Leipzig Vs Spartak Moscow
Barcelona Vs Galatasaray
Sevilla Vs West Ham United
Atalanta Vs Bayer Leverkusen
FC Porto Vs Olympique Lyon
Braga Vs AS Monaco
Rangers Vs Red Star Belgrade
