The match was originally scheduled for Thursday but could not come off after Tottenham announced 13 positive coronavirus cases in their camp.
Tottenham are now set to be eliminated from the competition, with UEFA referring the case to their control, ethics and disciplinary body for a final judgment.
Antonio Conte’s side, who are third in their group, are likely to be given a 3-0 loss, knocking them out of the competition.
A statement read: "Following a Covid-19 outbreak in the team of Tottenham Hotspur FC ahead of the UEFA Europa Conference League group stage match against Stade Rennais FC, scheduled to take place on 9 December 2021 in London, the match could not take place.
“In accordance with Annex J of the UEFA Europa Conference League regulations, UEFA, in cooperation with the two clubs tried to find a viable solution in order to reschedule the match, so as to ensure the group stage could be completed accordingly.
“Unfortunately, despite all efforts, a solution that could work for both clubs could not be found.
“As a consequence, the match can no longer be played and the matter will, therefore, be referred to the UEFA Control, Ethics and Disciplinary Body for a decision to be taken in accordance with Annex J of the above-mentioned competition regulations.”