It is the first time at the 1,008th game, Mourinho had a team that conceded six goals.
Speaking after the game, Mourinho who was not pleased with the result said;
"I over-estimated their capabilities.
"After going 3-1 down, we completely lost our heads and seemed to score every time they got the ball. The explanation is clear, they were stronger and it is my fault, because their first team is better than our second string. The side with the most quality won the game.
"It is my responsibility, I chose to use these players. However, if I had played the first team, someone might get injured or hurt, then we’d concede four or five goals against Napoli on Sunday and that decision would’ve been considered wrong too.
"When four or five weeks ago I said we had to go to the Vatican to pray for no injuries, I did know what I was talking about.
"The firs-team that Bodo put out today had more quality than our second string. Evidently, I must keep playing the same guys every game and take them to the limits of exhaustion."
Mourinho’s Roma are second behind Bodo Glimt with 6 points after three games.
The Giallorossi are back in action on Sunday as they face Luciano Spalletti's Napoli who are yet to lose a game in the Serie A this season.