Fofana got injured after a harsh tackle from Fer Nino and had to leave the pitch on a stretcher.
Leicester City won the match 3-2 thanks to goals from Caglar Soyuncu, Harvey Barnes and Ayoze Perez.
Fofana took to his Instagram page to disclose the news and believes to come back stronger.
“Hello guys, many thanks for all your messages. It is a bad day today but I am in a tremendous club with a wonderful medical team. I will give you news as soon as I have a final diagnosis but we already know that I have a fibula fracture. I will come soon and stronger: do not worry.”
Fofana was voted Leicester's young player of the season in 2020-21 after an impressive performances in the Premier League.
Since arriving at Leicester from Saint-Etienne in October for a fee reported to be in the region of £30 million, Fofana has remained a key cog for the side at the heart of defence.
The French defender has amassed 38 appearances in all competitions for the Foxes in his first spell with the club.
Leicester City will play Manchester City in the Community Shield on Saturday, before they open their league campaign at home to Wolves on August 14.
Fofana’s injury is a massive blow to Leicester City as they prepare for the upcoming season after finishing 5th in the league log last season.
