The opening weekend will see Premier League champions Manchester City travel to North London to face Tottenham Hotspurs. The Citizens reclaimed the title from Liverpool last season.
European champions Chelsea will host Crystal Palace at Stamford Bridge while Manchester United are at home to Marcelo Bielsa’s Leeds United.
Liverpool will travel to newcomers Norwich City, and Arsenal will face another newcomer in the shape of Brentford.
Leicester City will host Wolves on the opening day while Everton are at home to Southampton.
The North London, Manchester and Merseyside derbies for the first round will take place on September 25, November 6 and November 30 respectively.
The 2021/2022 season will conclude on May 22, 2022.
Premier League opening weekend fixtures
Brentford v Arsenal
Burnley v Brighton and Hove Albion
Chelsea v Crystal Palace
Everton v Southampton
Leicester City v Wolves
Manchester United v Leeds United
Newcastle United v West Ham
Norwich City v Liverpool
Tottenham v Manchester City
Watford v Aston Villa