The Red Devils have not won a trophy since Jose Mourinho led them to glory in the Europa League final in 2017 against Ajax in Stockholm, and will be bidding to end that drought when they face Unai Emery’s men.
Manchester United have somewhat progressed under Solskjaer this season, having gone the whole campaign without tasting defeat in away league games as they finished second in the Premier League.
Solskjaer knows that fighting for honours will be the only way to define his time at Old Trafford and hopes the Europa League will be the dawn of his side’s success.
"This is a team that we've rebuilt in the last few years, hopefully this is the start of something more," Solskjaer told reporters at a press conference.
"This is the best club in the world. That's the pleasure and the pressure of Manchester United. That's something the players are ready for. They wouldn't have signed here if they weren't top players.
"These are big nights for us. It might be the stepping stone for a big future.
"This group of players has been working for a year and a half together. The next step for them is to enjoy a game like this - I've seen something growing inside of the players."