Lloris lost his bearings while attempting to catch a routine cross from Pascal Gross on his goal-line but mistakenly dropped the ball allowing Neal Maupay the simplest of finishes.
The French shot-stopper was in visible pain and was given oxygen before he was stretched off following a five-minute spell on the pitch.
France’s world cup winning captain was replaced by Paulo Gazzaniga and was given a standing ovation from both the home and away fans.
The 32-year-old received morphine in the away dressing room before being taken to a hospital in an ambulance.
Prior to this mistake, he made another error last week, gifting Southampton striker Danny Ings an equalizer before conceding seven against Bayern Munich in midweek.
Tottenham Hotspurs looked to recover from their Champions League annihilation at the hands of the Germany champions but this incident on the South-Coast has compounded their misery as they eventually lost 3-0.
Although the extent of the damage is not known yet, Spurs now face being without their captain for an extended period of time.
Lloris was in contention to start for France in their upcoming matches against Iceland and Turkey in the EURO 2020 qualifiers but with this injury Didier Deschamps will turn his attention to fielding his second choice keeper, Alphonse Areola.
