Low has been in charge of the Die Mannschaft since 2006, leading them to world cup glory in 2014, but despite having one more year left on his contract, he has elected to end his tenure early.
Klopp has been earmarked as a potential successor to Low but the 53-year-old is not too keen on international management at this stage of his career.
Klopp has a contract with Liverpool until the summer of 2024 and despite overseeing a tumultuous domestic campaign so far this season, the former Borussia Dortmund manager has no intentions of walking away from Anfield.
"If I am available for coach of the German national team in the summer? No. After the summer? No,” Klopp told reporters when asked about links to his country’s top job ahead of Liverpool’s UEFA Champions League round of 16 second leg on Wednesday.
"I have three years left at Liverpool, that's a simple statement, a simple situation.
"You sign a contract and you normally try to stick to that contract don't you? I had a contract in Mainz where I stuck with them even though there was interest from other Bundesliga teams with more money.
"It is just timing and if it doesn't work out you don't have to lose any sleep over it.
"Jogi Low did an incredible job for so many years. I understand that he wants to have this highlight at the European Championship, try to squeeze everything out that he can in this tournament, and then somebody else will do the job.
"Someone else will do the job and I am pretty sure with the amount of really good German managers at the moment the German FA will find a good solution."