Liverpool have the advantage heading into the return encounter after running out 2-0 winners thanks to strikes from Mohamed Salah and Sadio Mane in the first leg.
The Reds are however reeling from losing a sixth straight home game in the Premier League over the weekend that has seen them all but surrender their title to Manchester City and face a huge task making the top four.
Leipzig on the other hand are still within touching distance of leaders Bayern Munich in the Bundesliga, sitting just two points behind the European champions.
Angelino is of the opinion that Leipzig have nothing to lose as they are underdogs ahead of the encounter against Jurgen Klopp’s men.
"It was tough because I thought we played a really good match," the RB Leipzig defender said while reflecting on the first leg.
"We were a few times behind their full-backs. [Trent] Alexander-Arnold on the ball is unbelievable but he is too offensive. But that is his best [quality] so we have to exploit the weakness and hopefully we can get a few more chances like we did in the first game. That was our mistake that we did not put them away.
"We could have put some pressure on them [by] scoring some of the chances we got. We felt we gave them two mistakes and a team like Liverpool, with the quality they have got, they kill you if you give them just a little bit.
"But we are positive because we played a strong match. If we don't make mistakes and we put our chances away, it can turn around, the situation. There is still 90 minutes to go and we will be focused and ready to go again. The pressure, I would say, is more on them than us. We are the underdog so we go from behind."
