The France international believes PSG will be seeking to avenge their elimination in the hands of Barcelona at this similar stage in 2017.
The Parisian comfortably won the first leg at home beating the Blaugrana 4-0 but the tie was turned on its head when Luis Enrique’s men did the unthinkable by winning 6-1 at Camp Nou to knock PSG out of the competition.
Ahead of Barcelona’s game at home against Mauricio Pochettino’s men on Tuesday, Dembele reflected on the famous ‘remontada’ against the Frenchmen, insisting his team-mates should be cautious.
"I think that game will go down in history, especially that of Barcelona," Dembele said in an interview with UEFA.com.
"The 4-0 [result] of the first leg is very difficult for any team in Europe to turn around, even more in the Champions League.
"But they did it with a great team with players like Neymar, Leo [Messi] or Andres Iniesta. "There will be an atmosphere of revenge.
“Also, thanks to the media that try to give life to things. However, we do not talk about it in the squad because we know it will be a difficult game.
"We know PSG, they are the current runners-up in the Champions League and they are among the favourites to win the title."