Mourinho’s men failed to build on their victory against West Bromwich Albion as Manchester City extended their lead at the summit to seven points.
Spain international Rodri put the Citizens ahead from the penalty spot on 23 minutes before in-form Ilkay Gundogan got the second on the 50th minute mark.
Manchester City scored their third goal on 66 minutes when Gundogan outmuscled Davinson Sanchez for a long pass forward from goalkeeper Ederson before tucking in his second of the game to take his tally to nine goals in nine Premier League games in 2021.
Tottenham have now lost four of their last five Premier League games (W1), as many defeats as in their previous 28 league matches.
"What do I make of the game? A fresh team against a very tired team, but a team that started the game very well. We controlled it, we hit the post, and going 1-0 could give us the fuel you need when you are tired,” Mourinho said after the game.
"And then they always win more of these modern penalties, I call them modern penalties, that put us in a difficult situation.
"A modern penalty is one where even if you touch with a nail it can be a penalty. It depends on the opponent. For some you touch with a nail it is a penalty, and the VAR cannot deny there is a touch with the toe or the nail or the nose. You cannot deny there is contact.
"We had nothing in our favour. But the second half was very difficult."
"I am very, very happy with the players' attitude. I had guys on the pitch who played two hours a couple of days ago and they gave everything. I had guys in a difficult situation on the pitch but they were brave.
"A team that is not united, not together would give up and would be punished, but I saw guys like Harry Kane, Ben Davies, Pierre-Emile Hojbjerg giving everything. I have nothing to say against my players, not even a couple of mistakes that are always present.