Mbappe had been stuck on 99 goals since scoring twice against former club AS Monaco on November 20 and had gone three games without a goal before netting in stoppage time, adding to goals from Colin Dagba and Moise Kean.
The 21-year-old France international joined PSG in the summer of 2017 and has so far won three Ligue 1 titles with the club.
His latest strike for the Parisians has taken him up to fourth on PSG’s all-time top scorers’ list, only behind Pauleta, Zlatan Ibrahimovic and Edinson Cavani.
"I knew my statistics, yes. It had been a few matches that I wanted to score the 100th," he told Canal+.
"This one wasn't the hardest. It's a liberation, especially at a big club like this and all the great players who have been here. When I signed here, I never thought I'd score 100 goals so quickly. It was part of the distant objectives.
"Thank you to my team-mates and to the club for giving me confidence, whether in good times or bad. Thank you to everyone who works there.
"I think I can score even more, offer more assists. It will come with time. I'm feeling better and better and going through matches will allow me to be even better physically."