Alvaro Morata’s 17th minute opener, Ferran Torres’ first career hattrick as well as Rodri and Mikel Oyarzabal’s goals condemned Germany to their worst ever defeat for 89 years on a forgettable night in Seville.
The defeat cost Germany a place in next year’s UEFA Nations League finals as Spain advanced at their expense, and Low was not happy at what he saw from his charges.
"It was an awful day for us, as nothing went right," he said, via DFB.de.
"There was nothing to be seen on the pitch in terms of our body language, the way we held ourselves and how we entered into challenges.
"Nothing was going right, neither in defence nor on offence. After conceding the opener we gave up on our game plan. We stormed forward and created gaps."
"We weren't organised and weren't communicating, which was fatal," Low added.
"We didn't have any control and didn't win any challenges. Tonight was a big setback for us. We need to analyse it and see where we can make adjustments.
"Today was extremely disappointing. We were bad in every respect tonight."