This is the third time the South Korean international has won the accolade after previous triumphs in September 2016 and April 2017. He is the first Spurs player since Lucas Moura in 2016 to claim the honour.
Son’s Spurs teammate Harry Kane, Chelsea’s Thiago Silva, Manchester City’s Kyle Walker, Aston Villa captain Jack Grealish, Che Adams of Southampton, West Ham United’s Pablo Fornals and Wolverhampton Wanderers skipper Conor Coady were all part of an eight-man shortlist for the award.
Son scored four goals and assisted two more during the month of October to help Jose Mourinho’s men move up the league table.
"Thanks for voting for me," he said after winning the award for a third time in his career.
"It's a big honour. I want to say thanks to my team-mates as I couldn't have won this without them."
The 28-year-old is currently the league’s joint top scorer with eight goals alongside Dominic Calvert-Lewin, Jamie Vardy and Mohamed Salah.
Everton’s Calvert-Lewin won the award last month.
Elsewhere, Wolverhampton Wanderers manager Nuno Esperito Santo came out on top as the manager of the month for October.
The Portuguese led Wolves to three wins from four games during the month and he beat Southampton’s Ralph Hasenhuttl, Dean Smith, Jose Mourinho and David Moyes to the award.