The North Londoners briefly went top of the Premier League on Sunday for the first time in six years after a 1-0 win against West Bromwich Albion at the Hawthorns.
Having had a bright start to the 2020/2021 season, Merson thinks Mourinho has what it takes to mount a title challenge with Spurs.
In his column for Sky Sports, the former Arsenal man believes Mourinho is an upgrade on Mauricio Pochettino, who was sacked as Tottenham manager in November 2019.
“It's a hard question to answer (can Spurs win the league?). They are going to be very reliant on Harry Kane,” he wrote.
“But, to be fair, results like the win at West Brom, they win you league titles. You look back on results like that and come what may, you remember it as a difficult game against one of the teams down at the bottom, who couldn't win a game but turned up on the day, and it turns out to be an important win.
“That's what you are up against if you want to win the Premier League. You watched West Brom against Fulham and they were atrocious. You start to think Tottenham have only got to turn up on Sunday morning and as long as they don't forget their boots, they'll win the game and move on.
“But in the end, it was a very hard game and Mourinho is probably sitting there asking himself why they didn't turn up and play like that against Fulham. That's how hard the Premier League is.
“Can Spurs go on and win the title? It's not impossible and that's because they've got a serial winner as a manager. They've got a chance because Mourinho is in charge and has won it before. He knows what it takes to get over the line.
“Can the players keep producing week in, week out? Only time will tell, but having Mourinho at the club gives them an advantage.
“Mauricio Pochettino was a good manager, don't get me wrong. However, they've now got more chance of winning the title because of Mourinho. He knows what you have to do week in, week out and then all over again.”
