United last won the Premier League in the 2012/2013 season during the legendary Sir Alex Ferguson’s final season in charge of the club.
Manchester City and Liverpool have taken over the Premier League in the last three seasons, with Guardiola’s men winning two of those and Klopp’s boys triumphing last season.
While Neville is convinced Ole Gunnar Solskjaer’s side will emerge champions of England again, the former England international also admits City and Liverpool have built dynasties that will not be easily toppled anytime soon.
"The one thing I can guarantee you is that United will win again," he told The Mirror.
"That might not be this year or next year, but it will be amazing when they win again, and the longer it builds up, the greater the actual feeling is when you do it.
"I'm not sitting here, as a United fan, thinking, 'We must win the league this year'. Yes, we'd like to, but you know when it's your time and it's not yet.
"It will be, maybe, when Klopp and Guardiola leave Liverpool and City - hopefully in the next couple of years!
"That will be the chance, as they're two outstanding managers who have built really good teams, but they'll leave in the next one, two or three years.
"That will be the point when United can come back in and capitalise - I'm sure Chelsea are thinking that way as well.”