Despite taking an early lead through Christian Pulisic, Frank Lampard’s men succumbed to two Pierre- Emerick Aubameyang goals to lose 2-1 at Wembley.
Skipper Cesar Azpilicueta was taken off ten minutes to half-time after hurting his hamstring, with Andreas Christensen taking the Spaniard’s place.
Goalscorer Pulisic suffered a similar fate early in the second half and his replacement Pedro Rodriguez, who is due to join AS Roma next season, also had to be stretchered off in stoppage time when he appeared to have dislocated his shoulder.
"I don't know the full extent of the injuries, but I know its the hamstrings with Azpi and Christian," manager Lampard said at his post-match news conference.
"They have to be scanned and assessed over the next few days. They clearly won't be fit for next week."
"I believe it could be a dislocated shoulder but don't go too soon on that," Lampard added when asked for an update on Pedro’s condition.
"I've not seen him yet as he was whisked away so it's a disappointing end as that's probably going to be his last game for Chelsea.
"He's been an incredible servant and I'm disappointed for him."