The virus originated from China in December 2019 and has currently killed over 370,000 people around the world.
Despite plans to restore normality after most part of the world was put on lockdown, Messi believes it will be hard to focus on football.
Messi and his team-mates are preparing for La Liga return after football came to a standstill in March as a result of Covid-19.
The 32-year-old has admitted that seeing people die and being unable to save or protect loved ones was really hard to take.
Messi told El Pais: "Most of us are left with doubts about what the world is going to be like after everything that has happened. Beyond the confinement and the situation that took us by surprise, many people had a really hard time because this situation affected them in some way, as it happened with all those who lost their family and friends and could not even see them.”
"I think there were a lot of negative things in this crisis, but there can be nothing worse than losing the people you love the most, that creates enormous frustration for me and seems to me the most unfair thing of all.
"Soccer, like life in general, I think will never be the same."
The Spanish season is set to resume on June 11 and Messi’s Barcelona will hope to continue from where they left off as they currently sit top of the La Liga table.