Ole Gunnar Solskjaer’s men, kind courtesy of Marcus Rashford’s brace and a goal apiece from Anthony Martial and substitute Daniel James, ensured Frank Lampard’s bow as Chelsea manager ended in disappointment.
The Red Devils move up to second place on the league table while Chelsea lie in 19th position after the first round of fixtures.
Chelsea almost took the lead in the 3rd minute when academy graduate Tammy Abraham pounced on a loose ball in the United penalty area and struck the post with a 20-yard strike.
Manchester United’s first chance of the game fell the way of Anthony Martial four minutes later, after Kurt Zouma’s stray pass fell the way of his fellow Frenchman, but the former AS Monaco forward hit a tame effort straight at Kepa Arrizabalaga.
The hosts were awarded a penalty in the 17th minute after Kurt Zouma’s clumsy challenge on Marcus Rashford in the box, and just like he did away to Paris Saint Germain in the Champions League last season, the young English striker picked himself up and buried the spot kick into the top left corner.
The visitors hit the woodwork for a second time through Emerson Palmieri with five minutes to half time after a driven ball from the right took out two United defenders.
Manchester United doubled their lead in the 65TH minute through Anthony Martial, who bundled home a low cross from Andreas Pereira to give the home side some breathing space.
Just a minute later, Chelsea’s day went from bad to worse when Marcus Rashford collected Paul Pogba’s glorious pass over the opposition’s defense and slotted past Kepa for his second of the day.
Substitute Daniel James, on for his Premier League debut, sealed the points for the Red Devils when he fed on Pogba’s pass in the 81st minute and struck a deflected effort past Kepa on a memorable day at Old Trafford.