Mane has established himself as one of the best forwards in the world since he joined Liverpool from Southampton in 2016.
The Senegal superstar’s stupendous record at Anfield has attracted big European clubs with Real Madrid and Barcelona reportedly yearning to secure his services.
Mane’s team-mate Mohamed Salah has also been linked with a move away from Liverpool in the summer.
Sissoko has admitted he does not know if Salah will leave Anfield, but believes Mane is ‘likelier’ to join Los Blancos.
“I see Mane at Real Madrid [more than Mohamed Salah],” the Malian told EuropaCalcio.it.
”He has the characteristics that [Zinedine] Zidane wants, I think Mane will go to Real Madrid.”
“I don’t know if Salah will stay at Liverpool. If he left, it could also be a good thing for Liverpool – they’re a clever club and they’d know how to replace him.”
“There are some fantastic youngsters who have what it takes to play for the Reds and put in top performances.”
Sissoko played for Liverpool between 2005 and 2008, where he made over 90 appearances before moving to Serie A side Juventus.
The 35-year-old also spoke of his fond memories of playing for the Reds and insists his time in England helped shape him as a man.
“Liverpool are something special: the fans, the club… I played with really terrific players there. Like Juventus, Liverpool also helped me to grow as a player and as a person.”
“It’s a shame that they’ve been knocked out of the Champions League, but it has to be said that the main aim was to win the Premier League. The fans have been waiting to win the title for a long time.”