Both Wenger and Ferguson stayed at Arsenal and Manchester United for 22 and 27 years respectively.
With Mauricio Pochettino and Unai Emery losing their jobs in the space of 10 days in North London, the former Chelsea and Manchester United manager believes the days of staying at a club for long is over.
Ahead of the Portuguese’s first league match at home as Tottenham head coach, the 56-year-old explained why the days of managers in the job are now numbered.
"Twenty years in a club? I don't think it's possible," Mourinho told reporters.
"Modern life, new technologies, social media - I think everything has an influence, even people's mentality, faster relations, getting tired easily, so many things that are changing.”
"Not [just] football but [these things] are changing the world and the perception of things that I think Wenger was the last 'man/one'. It's a bad thing for us.”
"We have to adapt and we have to try to prove that we are the man for the job. We have to fight for our job every day.”
"I think the times where people know the job is going to be mine for X amount of years [are gone]. You have to fight for your job every day. Not just with the football results but with everything you do in the club.”
"I think it's normal. It happens in society in so many areas. I can imagine even yourself in your newspaper and your radio you have to not just sleep on what you did previously.”
