Moura has spent five-and-a-half years in North London, having joined from Paris Saint Germain in January 2018.
The 30-year-old Brazilian has scored 38 goals in 219 appearances for Spurs.
Moura's finest moment in a Spurs shirt came away at Ajax Amsterdam in the Champions League semi-finals in 2019 when he scored a memorable hattrick to book a final spot with Liverpool.
But his contract will expire at the end of this season and it will not be renewed.
“Wherever I am, my heart will always be here. You are my club,” Moura said on Tottenham’s official Twitter feed.
“It has been the greatest honour to defend this badge. Every flick, every tackle, every leap, every goal.
“From the highest of highs to the lowest lows, from the beginning to the end, you sung my name. This has been my dream.
“This will always be my home. Some nights we will never forget, writing history together. I will always love you no matter where I go. We will meet again.”
Moura has made 17 appearances this season for Spurs and has struggled with injuries.
“We would like to thank Lucas for his tremendous service to our club and wish him the very best for the future,” an official club statement read.
“We shall provide a further update on our wider released and retained player list following the conclusion of the 2022/23 campaign.”
