Isak continued an impressive run of form by providing a sumptuous assist for Jacob Murphy in Thursday's 4-1 win at Everton in the Premier League.
Isak has scored 10 goals in 16 Premier League appearances since joining Newcastle for a club record £60m from Real Sociedad at the start of the season.
His form particularly after the World Cup has helped the Magpies continue their push for Champions League football next season.
Asked if he could see the comparison, head coach Howe said: “Yes, I can, I can see the comparisons there.
“Everyone is different, there are no two players that are the same, but I do think he has some of the characteristics Thierry had.
“He’s certainly got the speed and a similar build and frame. The footwork for the assist was truly remarkable, really, and I think he’s got a lot of potential to improve and get better.
“But it’s been a great start for him here.”
Asked if Isak has proved an even better player than he had anticipated, he said: “I don’t think you ever know with absolute certainty.
“Anyone who says that would be lying because until you work with a player close-up and you see them every day, I don’t think you ever know what their true capability is.
“But we’ve been very impressed with everything that he’s delivered to this point, not just technically on the pitch, but his character and how he’s handled certain situations. He’s been first class.”
Newcastle host relegation-threatened Southampton on Sunday.
