The duo were involved in Brazil’s game against rivals Uruguay in the early hours of Friday which means it will be impossible for them to be in England in time to face the Hornets.
Liverpool had wanted the game to be played in the evening but Watford declined the Reds’ humble request which means it will be a lunchtime kick-off.
Alisson and Fabinho will fly to Madrid directly from Brazil and wait for the team for their upcoming Champions League game against Atletico Madrid.
Klopp was speaking to the media ahead of Liverpool’s game against Claudio Ranieri’s men and the German coach castigated the quarantine rules.
"We had to sort quarantine issues and the decision we made is the boys will not be here, they will go directly to Madrid, wait there for us, hopefully be able to play against Atletico, then will come back slightly later than us, so then they can come back in our normal procedure again," he said.
"Obviously they could have flown into England but with all the quarantine stuff that would have meant they would have to isolate from their families and Ali has three kids and being away with the national teams and then 10 days in isolation with the same rubbish again... we need solutions for that and they are still not there.
"They have played in Brazil so they already had four days there not in a red-list country and that's what counts. "Then another six days not in a red-list country then they can come back and start immediately so even when they go from bubble to bubble to bubble it is still 10 days and for us that is the solution."
