Santo believes the players must be protected amid the second wave of Covid-19 in Europe.
Rui Patricio, full-back Nelson Semedo, midfielders Ruben Neves and Joao Moutinho and forward Daniel Podence have all been away with Portugal during international break, where team-mate Cristiano Ronaldo tested positive for Covid-19.
Santo is hoping his Portuguese players have returned from international duty coronavirus free and has urged FIFA to suspend international football to check the spread of Covid-19.
"We've been tested. We have a new system of testing now that allows us not to make any mistakes when coming back from international games. Let's wait to find out the results, but for now everybody is healthy," the former Valencia coach said.
"It will probably be Sunday morning that we have the final results, so you can see how it affects the decisions and how you prepare for a game. You prepare and put things in place and work on things but if a (positive) result comes back then you have to take the player out.
"If you ask me what we should do in the middle of a global pandemic, my answer would be for sure to stop. I don't think the schedule for international teams was well prepared."
