The players selected include Bryan Mbuemo, Mohamed Salah, Declan Rice, Douglas Luiz, Pedro Neto and Cristian Romero.
So far this season, two Tottenham Hotspurs players, James Maddison and Son Heung-Min, have won player of the month awards for August and September.
With Romero in contention this time, it remains to be seen whether the North London side will make it three on the spin.
Romero helped Spurs keep two clean sheets in their three games in October and assume top spot on the table.
Rice scored once and assisted another in three games for Arsenal, which kept them within touching distance of the league leaders.
Salah scored five goals in October for Liverpool, including braces against Brighton and Hove Albion and Everton.
Neto recorded assists in each of Wolverhampton Wanderers' three matches last month while produced two goals and two assists for Brentford.
Luiz was instrumental in a resurgent Aston Villa side who won two games and drew once, with the Brazilian midfielder scoring twice and assisting once.
Elsewhere, Ange Postecoglou is in the frame for manager of the month again, having claimed awards in August and September.
Mikel Arteta, Unai Emery and Jurgen Klopp will provide the Australian with competition this time around.
