Tyler has been Sky Sports' lead commentator since the Premier League's inception in 1992.
The 77-year-old has presided over some of the Premier League's most iconic moments, including Sergio Aguero's last-minute winner that won Manchester City the title in 2012.
Tyler previously worked with ITV in the 1980's before joining Sky Sports in 1990.
In a statement on the Sky Sports website, Tyler said: “In my humble opinion, the huge corporation Sky is today has stemmed from Sky Sports’ innovative and inspired coverage of the Premier League.
“It has been a privilege to play a small part in the broadcasting history of the greatest league in the world.
“Along the way I have worked alongside legions of wonderful professionals in all aspects of the television industry. I thank them all for their support and expertise. It has been an honour to be a member of a very gifted team.”
Richard Masters, Premier League chief executive, said: "Martin has had an incredible broadcasting career, spanning nearly 50 years commentating on football, and his voice has been synonymous with the Premier League since it began in 1992.
"He has made a remarkable contribution to the game and there will be generations of football fans who will always remember his words in those big game moments, and of course 'that goal' by Aguero on the last day of the 2012 season.
"Whether on Sky Sports, ITV or globally through his work with Premier League Productions and other international broadcasters, covering Premier League games, European matches or World Cups, Martin's insightful commentary and analysis has always added something special to games.
"I would like to thank Martin on behalf of everyone at the Premier League for the incredible role he has played and we will miss hearing him from the Sky Sports commentary box."
