Neymar has remained on the sidelines since suffering the injury against Lille in Ligue 1 last month.
PSG have announced that the Brazil international will require surgery which expected to rule him out for up to four months.
A statement from the Ligue 1 champions read: "Neymar Jr has featured several episodes of right ankle instability in recent years.
"Following his last sprain contracted on February 20, the Paris Saint-Germain medical staff recommended a ligament repair operation, in order to avoid a major risk of recurrence. All the experts consulted confirmed this need.
"This surgery will be performed in the coming days at ASPETAR Hospital in Doha.
"A delay of three to four months is expected before his return to collective training."
The prognosis of the injury means the 31-year-old will miss PSG's Champions League round of 16 second leg clash against Bayern Munich at the Allianz Arena on Wednesday.
PSG trail 1-0 from the first leg played in France a fortnight ago.
Neymar has scored 18 goals and provided 17 assists in 29 appearances across all competitions this season.
PSG are eight points clear at the top of the Ligue 1 standings.
