Only a maximum of 15,000 spectators will be allowed entry in new measures aimed at reducing rising infection rates.
Over 70,000 infections and 388 deaths were recorded in Germany on Thursday.
"The DFL is aware of the currently difficult corona situation, especially with a view to the strain on some regional health systems," German Football League (DFL) chief Christian Seifert said in a statement.
"It is regrettable that, due to the pandemic situation and the still too low vaccination rate in Germany, restrictions in many areas of life are once again necessary.
"In this situation, a differentiated, comprehensible, but above all effective policy strategy is required.
"A temporary restriction on the admission of fans to the stadiums is therefore understandable. The DFL hopes that this decision by the federal and state governments will lay the foundation for a rapid improvement in the pandemic situation.
"The DFL and its clubs will of course continue to support all vaccination effort."
Among matches to be impacted by the new measures is Borussia Dortmund against Bayern Munich, with the two teams separated by a point at the top of the table.