Both Fabinho and Alisson are still on international duty and will be in the Brazil squad to face Uruguay at 1.30am on Friday morning UK time.
The game will kick-off just 35 hours before Jurgen Klopp’s side’s lunchtime encounter against the Hornets.
Liverpool have reportedly made a humble plea to move the game to an evening kick-off but the Hertfordshire-based club have declined the Red’s request.
Fabinho has revealed that it will be very difficult for him together with Alisson to make it back in time to face Claudio Ranieri’s side.
“I believe that this first match against Watford it will be very hard for us, I don't think we will play. Neither Alisson or myself,” the midfielder said.
“The match against Uruguay will be Friday overnight there (in the United Kingdom) and the match against Watford will be half past noon.
“With all of what is involved, travel, I don't know how much time we will have between one game and the other.
“I believe that we won't be playing. We will also be in quarantine, but the club is still studying whether it is better to go straight to Spain to play against Atletico Madrid and quarantine there, without staying in a hotel in England.”